Apr 06, 2017
A research team has ascertained that juveniles who are volunteering in a clinical trial to evaluate the potency of decreased radiotherapy actually worsened when the treatment protocol diverged. The results of the study are made available online of publication by Pediatric Blood & Cancer.
MD, the first author on the study and a radiation oncologist at Children's Hospital Los Angeles, Kenneth K. Wong believes that the clinical trial depicts that the concentration to the dosage, timing and location of the radiation therapy is quite critical.
This study is a qualitative evaluation of the Head Start III trial that prevents of impedes radiation therapy in children suffering from brain tumors. The Head Start trial depicts a novel pioneering approach for treating the brain tumors that are malignant by making use of extreme dose of chemotherapy subsequently by blood stem cells transfusion. This technique is an alternative to radiation in much younger children, wherein the delayed harmful effects of radiation to the brain which is developing could be specifically damaging. If the tumor continues to exist even post the treatment session or if the child is older, they get radiation therapy.
Since the primary aim of this study is to decrease the amount of radiation exposure, in the Head Start III, only 31 out of 220 children experienced radiation as a part of the study.
Nevertheless, out of the 31 children, a set of 8 of 25 children had divergence from the treatment plan. These protocol infringements happened in children who are of 6 years old and younger.
Wong said, "Parents or providers may want to delay the start of radiation or reduce the dose or area of exposure - particularly in very young children." however, he says that in a study which is already encouraging decrease of radiation, patients with these types of divergence in routine protocols went through worse results.
Children who were entitled for radiation therapy, out of them, the ones that got treatment as per the protocol and started with the radiation therapy within 11 weeks of recovery from stem cell transfusion and bettered the chances of overall survival.
In order to enhance the results of the treatment in children, Wong proposes aiming on decreasing the protocol violations by evaluating the plan of the treatment before beginning the radiation therapy. He is presently engaging on financing to continue this work.
Apr 11, 2017
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