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Anisindione: Recent Study including Growth Factors, Applications, Regional Analysis, Key Players and Forecasts

May 19, 2017

Anisindione: Recent Study including Growth Factors, Applications, Regional Analysis, Key Players and Forecasts

Anisindione (brand name Miradon) is a synthetic anticoagulant and an indanedione derivative. It prevents the formation of anticoagulant proteins C and S, as well as active procoagulation factors II, VII, IX, and X in the liver by reducing the vitamin K. This results in inhibition of gamma-carboxylation of precursor protein glutamic acid to gamma-carboxyglutamic acid. The resultant effect of all these reactions in the body is prolongation of blood clotting time and reduced activity of clotting factors. Anisindione is used for treatment of atrial fibrillation with embolization, the prophylaxis and treatment of venous thrombosis, the prophylaxis and treatment of pulmonary embolism, disseminated intravascular coagulation and treatment of coronary occlusion.

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Molecular Formula of Anisindione is C16H12O3

synonyms-2-(4-methoxyphenyl)-1H-indene-1,3(2H)-dione,2-para-Anisyl-1,3-indandione,2-(p-Methoxyphenyl)indane-1,3-dione, Unidone, Anisindionum

Methods of manufacturing

Anisindione is prepared from anisaldehyde and phthalide in sodium alcoholate. The alternate method of fabricating this compound is from 1-p-methoxybenzalphthalide and sodium methoxide.

Adverse reactions

Apart from hemorrhagic disorders, other adverse reactions include nausea and vomiting, abdominal cramps, diarrhea,  pyrexia, anorexia, dermatitis or exfoliative dermatitis, sore throat, jaundice,  hepatitis, anemia ,   liver damage, dermatitis,  headache,  urticaria, erythema and necrosis of the skin and other tissues alopecia, leukopenia, myeloid  immaturity,  paralysis  of  accommodation of eyes,  sore mouth or mouth ulcers, priapism, albuminuria, eosinophilia, red cell aplasia, steatorrhearenal tubular necrosis,   blurred vision, anuria, thrombo-cytopenia    purple toes, atypical mononuclear cells, leukocytosis, leukocyte agglutinins, agranulocytosis,  cutaneous gangrene and Phenprocoumon-induced delayed callus formation after  bone  fracture.

Contraindications

  • History or tendency of bleeding, hemophilia, purpura,  polycythemia vera,  leukemia, cerebral hemorrhage which has taken place recently, ulcers in the the gastrointestinal tract, ulcerative colitis, wounds due to trauma or  wounds from surgery
  • recent or planned eye surgery, brain surgery,  or surgery of spinal cord  or prostatectomy
  • Patients with continuous tube drainage of small gut
  • Visceral carcinoma, severe kidney disease, severe liver disease, pericarditis, subacute bacterial endocarditis,   diverticulitis, polyarthritis or aneurysm.
  • malignant severe or  hypertension, threatened abortion, preeclampsia or eclampsia,
  • Malnutrition, emaciation, and vitamin K or C deficiencies.
  • Pregnancy - Anisindione is not to be used during pregnancy as the drug travels across the placental barrier and can cause damage to fetus. Hemorrhage of neonate or Fetus and intrauterine fetal death have happened even when the level of prothrombin in mother were within the accepted range. Other disorders like hypoplasia of nasal structures, Conradi-Hunermann syndrome may occur. Other alternatives like heparin, which does not cross the placenta, need to be used in cases of pregnancy.

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Table of Contents

Global Anisindione Sales Market Report 2017
1 Anisindione Market Overview
1.1 Product Overview and Scope of Anisindione
1.2 Classification of Anisindione by Product Category
1.2.1 Global Anisindione Market Size (Sales) Comparison by Type (2012-2022)
1.2.2 Global Anisindione Market Size (Sales) Market Share by Type (Product Category) in 2016
1.2.3 Oral Drugs
1.2.4 Injectable Drugs
1.3 Global Anisindione Market by Application/End Users
1.3.1 Global Anisindione Sales (Volume) and Market Share Comparison by Application (2012-2022)
1.3.2 Anticoagulant
1.3.3 Protein Hydrolysis
1.3.4 Others
1.4 Global Anisindione Market by Region
1.4.1 Global Anisindione Market Size (Value) Comparison by Region (2012-2022)
1.4.2 United States Anisindione Status and Prospect (2012-2022)
1.4.3 China Anisindione Status and Prospect (2012-2022)
1.4.4 Europe Anisindione Status and Prospect (2012-2022)
1.4.5 Japan Anisindione Status and Prospect (2012-2022)
1.4.6 Southeast Asia Anisindione Status and Prospect (2012-2022)
1.4.7 India Anisindione Status and Prospect (2012-2022)
1.5 Global Market Size (Value and Volume) of Anisindione (2012-2022)
1.5.1 Global Anisindione Sales and Growth Rate (2012-2022)
1.5.2 Global Anisindione Revenue and Growth Rate (2012-2022)

2 Global Anisindione Competition by Players/Suppliers, Type and Application
2.1 Global Anisindione Market Competition by Players/Suppliers
2.1.1 Global Anisindione Sales and Market Share of Key Players/Suppliers (2012-2017)
2.1.2 Global Anisindione Revenue and Share by Players/Suppliers (2012-2017)
2.2 Global Anisindione (Volume and Value) by Type
2.2.1 Global Anisindione Sales and Market Share by Type (2012-2017)
2.2.2 Global Anisindione Revenue and Market Share by Type (2012-2017)
2.3 Global Anisindione (Volume and Value) by Region
2.3.1 Global Anisindione Sales and Market Share by Region (2012-2017)
2.3.2 Global Anisindione Revenue and Market Share by Region (2012-2017)
2.4 Global Anisindione (Volume) by Application

3 United States Anisindione (Volume, Value and Sales Price)
3.1 United States Anisindione Sales and Value (2012-2017)
3.1.1 United States Anisindione Sales and Growth Rate (2012-2017)
3.1.2 United States Anisindione Revenue and Growth Rate (2012-2017)
3.1.3 United States Anisindione Sales Price Trend (2012-2017)
3.2 United States Anisindione Sales Volume and Market Share by Players
3.3 United States Anisindione Sales Volume and Market Share by Type
3.4 United States Anisindione Sales Volume and Market Share by Application

4 China Anisindione (Volume, Value and Sales Price)
4.1 China Anisindione Sales and Value (2012-2017)
4.1.1 China Anisindione Sales and Growth Rate (2012-2017)
4.1.2 China Anisindione Revenue and Growth Rate (2012-2017)
4.1.3 China Anisindione Sales Price Trend (2012-2017)
4.2 China Anisindione Sales Volume and Market Share by Players
4.3 China Anisindione Sales Volume and Market Share by Type
4.4 China Anisindione Sales Volume and Market Share by Application

5 Europe Anisindione (Volume, Value and Sales Price)
5.1 Europe Anisindione Sales and Value (2012-2017)
5.1.1 Europe Anisindione Sales and Growth Rate (2012-2017)
5.1.2 Europe Anisindione Revenue and Growth Rate (2012-2017)
5.1.3 Europe Anisindione Sales Price Trend (2012-2017)
5.2 Europe Anisindione Sales Volume and Market Share by Players
5.3 Europe Anisindione Sales Volume and Market Share by Type
5.4 Europe Anisindione Sales Volume and Market Share by Application

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6 Japan Anisindione (Volume, Value and Sales Price)
6.1 Japan Anisindione Sales and Value (2012-2017)
6.1.1 Japan Anisindione Sales and Growth Rate (2012-2017)
6.1.2 Japan Anisindione Revenue and Growth Rate (2012-2017)
6.1.3 Japan Anisindione Sales Price Trend (2012-2017)
6.2 Japan Anisindione Sales Volume and Market Share by Players
6.3 Japan Anisindione Sales Volume and Market Share by Type
6.4 Japan Anisindione Sales Volume and Market Share by Application

7 Southeast Asia Anisindione (Volume, Value and Sales Price)
7.1 Southeast Asia Anisindione Sales and Value (2012-2017)
7.1.1 Southeast Asia Anisindione Sales and Growth Rate (2012-2017)
7.1.2 Southeast Asia Anisindione Revenue and Growth Rate (2012-2017)
7.1.3 Southeast Asia Anisindione Sales Price Trend (2012-2017)
7.2 Southeast Asia Anisindione Sales Volume and Market Share by Players
7.3 Southeast Asia Anisindione Sales Volume and Market Share by Type
7.4 Southeast Asia Anisindione Sales Volume and Market Share by Application

8 India Anisindione (Volume, Value and Sales Price)
8.1 India Anisindione Sales and Value (2012-2017)
8.1.1 India Anisindione Sales and Growth Rate (2012-2017)
8.1.2 India Anisindione Revenue and Growth Rate (2012-2017)
8.1.3 India Anisindione Sales Price Trend (2012-2017)
8.2 India Anisindione Sales Volume and Market Share by Players
8.3 India Anisindione Sales Volume and Market Share by Type
8.4 India Anisindione Sales Volume and Market Share by Application

9 Global Anisindione Players/Suppliers Profiles and Sales Data
9.1 Aimpow
9.1.1 Company Basic Information, Manufacturing Base and Competitors
9.1.2 Anisindione Product Category, Application and Specification
9.1.2.1 Product A
9.1.2.2 Product B
9.1.3 Aimpow Anisindione Sales, Revenue, Price and Gross Margin (2012-2017)
9.1.4 Main Business/Business Overview
9.2 Toronto Research Chemicals
9.2.1 Company Basic Information, Manufacturing Base and Competitors
9.2.2 Anisindione Product Category, Application and Specification
9.2.2.1 Product A
9.2.2.2 Product B
9.2.3 Toronto Research Chemicals Anisindione Sales, Revenue, Price and Gross Margin (2012-2017)
9.2.4 Main Business/Business Overview
9.3 Santacruz Biotechnology
9.3.1 Company Basic Information, Manufacturing Base and Competitors
9.3.2 Anisindione Product Category, Application and Specification
9.3.2.1 Product A
9.3.2.2 Product B
9.3.3 Santacruz Biotechnology Anisindione Sales, Revenue, Price and Gross Margin (2012-2017)
9.3.4 Main Business/Business Overview

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