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Novartis to strengthen home rights to Lubris’ eye drug

Apr 07, 2017

Novartis to strengthen home rights to Lubris’ eye drug

Novartis reported that it has practiced a choice to in-licence ECF843 for ophthalmic signs around the world. The settling of the deal is liable to standard closing circumstances including authoritarian approvals. The financial and different terms of this deal are not revealed.

"ECF843 has the potential to be the first therapeutic to provide rapid relief of dry eye symptoms and significantly improve signs. Exercising our option to in-license ECF843, along with our recent acquisition of Encore Medical for the treatment of presbyopia, underscores our commitment to treating diseases of the front of the eye which impact millions of people worldwide" said by the Global Head, Drug Development and Chief Medical Officer, Novartis, Mr. Vasant Narasimhan.

ECF843 is a recombinant human lubricin (rh-Lubricin) protein, which, in a Phase II clinical trial, demonstrated potential to give rapid change of indications likely by expanding lubrication across over different eye and tear surfaces together with a change in indications of dry eye within 28 days without announcing treatment related adverse events.

Deficiency of lubricin protein is seen in dry eye patients. Lubricin is an endogenous glycoprotein transmitted in areas of high shear stress and friction including the tear film where it ties to and secures tissues of the ocular surface, the assumed system that ECF843 addresses. ECF843 is another medical approach and a potential first-in-class Rx treatment in dry-eye, which is an area of high unmet therapeutic need affecting more than 344 million patients all around the globe. ECF843 is hypothesized to restore the tear film function, decrease friction and calm the signs and indications of dry eye.

If it does well, the drug’s competition for share of the substantial dry eye market will comprise Shire’s Xiidra (lifitegrast), which was launched in the United States last year, and Allergan’s veteran megahit Restasis (cyclosporine).

The financial and several other conditions of the deal, which stays subject to regulatory closing conditions, even the regulatory approvals were kept a hush.

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